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KMID : 1138520080110010163
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Journal of Pharmacopuncture
2008 Volume.11 No. 1 p.163 ~ p.176
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The Effect of Bangpungtongsung-san Extracts on Adipocyte Metabolism
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Lee Sang-Min
Kim Byoung-Woo
Rhim Tae-Jin
Kim Dong-Heui
Kwon Ki-Rok
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Abstract
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Objective : The purpose of this study is to investigate the effects of Bangpungtongsung-san extracts on the preadipocytes proliferation, of 3T3-L1 cell line. lipolysis of adipocytes in rat’s epididymis and localized fat accumulation of porcine by extraction methods(alcohol and water).
Methods : Diminish 3T3-L1 proliferation and lipogenesis do primary role to reduce obesity. So, 3T3-L1 preadipocyte and adipocytes were performed on cell cultures, and using Sprague-Dawley rats for the lipogenesis, and treated with 0.01- Bangpungtongsung-san Extracts depend on concentrations. Porcine skin including fat tissue after treated Bangpungtongsung-san Extracts by means of the dosage dependent variation are investigated the histologic changes after injection of these extracts.
Results : Following results were obtained from the 3T3-L1 preadipocyte proliferation and lipolysis of adipocyte in rats and histologic investigation of fat tissue. 1. Bangpungtongsung-san extracts were showed the effect of decreased preadipocyte proliferation on the high dosage(). 2. Bangpungtongsung-san extracts were showed the effect of decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) on the high dosage() and Specially, alcohol extract of Bangpungtongsung-san was clear as time goes by high concentration. 3. Bangpungtongsung-san extracts were showed tries to compare the effect of lipolysis, alcohol extract of Bangpungtongsung-san on the high dosage() was observed the effect is higher than water extract. 4. Investigated the histological changes in porcine fat tissue after treated Bangpungtongsung-san extracts, we knew that water extract of Bangpungtongsung-san was showed the effect of lipolysis on the high dosage() and alcohol extract of Bangpungtongsung-san was showed significant activity to the lysis of cell membranes in all concentration.
Conclusion : These results suggest that Bangpungtongsung-san efficiently induces diminish proliferation of preadipocyte and lipolysis in adipose tissue.
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KEYWORD
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Bangpungtongsung-san, alcohol extract, Water extracts, 3T3-L1 preadipocyte, adipocytes, lipolysis, Fat tissues
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